Non-Invasive Detection of Early Stage Cancer by Analyzing the Fragmentation and Biological Features of Cell-Free DNA

Grant number: 12822 | Funding period: 2020 - 2023

Completed

Abstract

Background In recent years it has been discovered that relatively small fragments of genetic material (the genome), especially DNA, can pass from cells to blood and urine. This so-called cell-free DNA can say something about the health status of individuals and is now widely used in prenatal diagnostics. The so-called non-invasive pregnancy test (NIPT) is an example of this. This testing is also called 'liquid biopsies' and can also be used for the detection of cancer on the basis of tumor DNA fragments that escape from tumor tissue and circulate in the blood Traditionally, ctDNA has been detected by measuring the presence of tumor-specific genetic mutations. Methods based on testing cancer-..

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